Alessandro Arduini is a Senior Research Scientist in the Ellinor’s team. His dream as a child was to become an “inventor”; his passion for discovery and research initially took him to study human exercise physiology, and eventually experimental biology in a large range of disease areas. He had opportunities to learn from several laboratories across Italy, Spain and US. Since 2017, he is a member of Precision Cardiology Laboratory at Broad. He is responsible for projects driving both knowledge generation to address critical questions in the area of cardiovascular disease and therapeutics development, with wide expertise in assay development, preclinical models and project coordination. One of the areas of work is generation of single cell resolution information of the cardiovascular system, with aim of identifying targets for therapeutic intervention. Alessandro has done significant work on the intersection between nutrients and cellular responses, both in normal physiology and organelle stress – also in the context of metabolic and inflammatory diseases. Throughout his career, he elucidated some mechanistic aspects of sensing, signal transduction and stress responses relevant to human disease, using either cellular and animal models, or human patients. Arduini obtained his bachelor degree at the Universita’ Statale di Milano (Italy), and Ph.D. in physiology at the School of Medicine of the University of Valencia (Spain). His full list of contributions encompasses research in obesity, NASH, diabetes, atherosclerosis, vascular biology, obstructive jaundice, prematurity and exercise.