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Ellinor LabEllinor Lab
Using genetics to identify new pathways and
therapeutic targets for cardiovascular diseases
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Selected Publications

Selected Publications

The full list of Dr. Ellinor’s publications is available here.

Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank

February 17, 2022

Sean J. Jurgens, Seung Hoan Choi, Valerie N. Morrill, Mark Chaffin, James P. Pirruccello, Jennifer L. Halford, Lu-Chen Weng, Victor Nauffal, Carolina Roselli, Amelia W. Hall, Matthew T. Oetjens, Braxton Lagerman, David P. vanMaanen, Regeneron Genetics Center, Krishna G. Aragam, Kathryn L. Lunetta, Christopher M. Haggerty, Steven A. Lubitz & Patrick T. Ellinor

Deep learning enables genetic analysis of the human thoracic aorta

November 26, 2021

James P. Pirruccello, Mark D. Chaffin, Elizabeth L. Chou, Stephen J. Fleming, Honghuang Lin, Mahan Nekoui, Shaan Khurshid, Samuel F. Friedman, Alexander G. Bick, Alessandro Arduini, Lu-Chen Weng, Seung Hoan Choi, Amer-Denis Akkad, Puneet Batra, Nathan R. Tucker, Amelia W. Hall, Carolina Roselli, Emelia J. Benjamin, Shamsudheen K. Vellarikkal, Rajat M. Gupta, Christian M. Stegmann, Dejan Juric, James R. Stone, Ramachandran S. Vasan, Jennifer E. Ho, Udo Hoffmann, Steven A. Lubitz, Anthony A. Philippakis, Mark E. Lindsay & Patrick T. Ellinor

Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signaling

November 26, 2021

Qiuyu Martin Zhu, Bryan T MacDonald, Taiji Mizoguchi, Mark Chaffin, Alison Leed, Alessandro Arduini, Edyta Malolepsza, Kasper Lage, Virendar K Kaushik, Sekar Kathiresan, Patrick T Ellinor

Coronary Disease Association with ADAMTS7 is due to Protease Activity

June 28, 2021

Taiji Mizoguchi, Bryan T MacDonald, Bidur Bhandary, Nicholas R Popp, Dylan Laprise, Alessandro Arduini, Daniel Lai, Qiuyu Martin Zhu, Yi Xing, Virendar K Kaushik, Sekar Kathiresan, and Patrick T Ellinor

Genetic Risk Score to Identify Risk of Venous Thromboembolism in Patients with Cardiometabolic Disease

January 12, 2021

Marston NA, Melloni GEM, Gurmu Y, Bonaca MP, Kamanu FK, Roselli C, Lee C, Cavallari I, Giugliano RP, Scirica BM, Bhatt DL, Steg PG, Cohen M, Storey RF, Keech AC, Raz I, Mosenzon O, Braunwald E, Lubitz SA, Ellinor PT, Sabatine MS, Ruff CT

Non-Vitamin K Antagonist Oral Anticoagulant vs Warfarin for Post Cardiac Surgery Atrial Fibrillation

January 10, 2021

Nauffal V, Trinquart L, Osho A, Sundt TM, Lubitz SA, Ellinor PT.

Ibrutinib-Mediated Atrial Fibrillation Attributable to Inhibition of C-Terminal Src Kinase

December 22, 2020

Xiao L, Salem JE, Clauss S, Hanley A, Bapat A, Hulsmans M, Iwamoto Y, Wojtkiewicz G, Cetinbas M, Schloss MJ, Tedeschi J, Lebrun-Vignes B, Lundby A, Sadreyev RI, Moslehi J, Nahrendorf M, Ellinor PT, Milan DJ.

Identification of two preclinical canine models of atrial fibrillation to facilitate drug discovery

December 17, 2020

Freudenberger T, Kranz B, Lehmann W, Schäfer K, Münter K, Lee K, Ellinor PT, Hucker WJ.

Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation

December 13, 2020

Hall AW, Chaffin M, Roselli C, Lin H, Lubitz SA, Bianchi V, Geeven G, Bedi K, Margulies KB, de Laat W, Tucker NR, Ellinor PT.

Clinical Application of a Novel Genetic Risk Score for Ischemic Stroke in Patients with Cardiometabolic Disease

November 13, 2020

Marston NA, Patel PN, Kamanu FK, Nordio F, Melloni GM, Roselli C, Gurmu Y, Weng LC, Bonaca MP, Giugliano RP, Scirica BM, O’Donoghue ML, Cannon CP, Anderson CD, Bhatt DL, Steg PG, Cohen M, Storey RF, Sever P, Keech AC, Raz I, Mosenzon O, Antman EM, Braunwald E, Ellinor PT, Lubitz SA, Sabatine MS, Ruff CT.

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