Sebastian Clauss obtained his medical degree in 2009 from the Ludwig-Maximilians-University (LMU) in Munich, Germany. After medical school he started his clinical fellowship in Internal Medicine and Cardiology at Klinikum Grosshadern in Munich.

He started his scientific training in 2006 in the laboratory of Prof. H.-J. Anders where he worked on chemokine signaling in chronic kidney disease. He continued his scientific training in the laboratory of Prof. S. Nattel at the Montreal Heart Institute in 2009 where he worked on microRNA mediated mechanisms leading to atrial fibrillation. In 2010 he joined the laboratory of Prof. S. Kb in Munich where he continued his work on proarrhythmogenic signaling in atrial fibrillation.

He joined the Ellinor lab in June 2013 to evaluate the functional impact of GWAS hits in atrial fibrillation using knockout mouse models.